25(OH)D3 and cardiovascular risk factors in female nonhuman primates.
Publication/Presentation Date
9-1-2012
Abstract
OBJECTIVE: To determine if interindividual differences in plasma concentrations of 25-hydroxyvitamin D(3) (25(OH)D(3)) have pathophysiologic significance, we evaluated a cohort of female monkeys, seeking to identify associations with clinically relevant cardiovascular risk factors, including age, abdominal obesity (waist circumference), and high-density lipoprotein cholesterol (HDL-C).
METHODS: One hundred fifty-five female vervet monkeys (Chlorocebus aethiops sabaeus) aged 3-25 years consumed a typical western diet for 7-8 weeks that provided a woman's equivalent of approximately 1000 IU/day of vitamin D(3). Measurements of vitamin D(3) and HDL-C concentrations, as well as waist circumference, were obtained.
RESULTS: Among young monkeys (aged 3-5 years), compared to older monkeys (aged 16-25 years), the mean plasma 25(OH)D(3) concentrations were 82.3±3.2 ng/mL and 58.6±2.9 ng/mL (p
CONCLUSIONS: Higher plasma concentrations of 25(OH)D(3) were associated with more favorable cardiovascular risk factors, with inverse associations observed between 25(OH)D(3) and abdominal obesity, HDL-C, and age. These associations were no longer significant when controlling for age.
Volume
21
Issue
9
First Page
959
Last Page
965
ISSN
1931-843X
Published In/Presented At
Jorgensen, M. J., Rudel, L. L., Nudy, M., Kaplan, J. R., Clarkson, T. B., Pajewski, N. M., & Schnatz, P. F. (2012). 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. Journal of women's health (2002), 21(9), 959–965. https://doi.org/10.1089/jwh.2011.3416
Disciplines
Medicine and Health Sciences
PubMedID
22876774
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article