Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density.
Publication/Presentation Date
8-1-2012
Abstract
INTRODUCTION: This study analyzed associations between plasma vitamin D(3) (25OHD(3)) and bone mineral density (BMD) and whether the effects of conjugated equine estrogens (CEE) on BMD are modulated by 25OHD(3).
METHODS: Fifty cynomolgus monkeys were fed a diet containing 25OHD(3) (providing a woman's equivalent of 1000 IU/day of 25OHD3). The monkeys underwent bilateral oophorectomy and were randomized to either CEE (equivalent of 0.45 mg/day) (n=25) or placebo (n=25) and continued receiving the same diet. 25OHD(3) and BMD were measured at randomization and after 6 months. BMD also was measured after 20 months (equivalent to 6 human years). Associations between 25OHD(3) and BMD were subsequently analyzed.
RESULTS: Baseline 25OHD(3) plasma concentrations varied from 26 to 95 ng/mL (mean±standard deviation [SD] 54 ± 15 ng/mL). Higher plasma concentrations of 25OHD(3) were associated with a significantly increased BMD. Monkeys on both CEE and placebo had increased BMD over 20 months; however, the increase was not significantly different (0.034 g/cm(2) vs. 0.020 g/cm(2), respectively; p=0.064). The 20-month BMD increased significantly with CEE treatment in those with higher vs. lower 25OHD(3) concentrations (p=0.027). The percent change in BMD over 20 months also increased significantly with CEE treatment in those with higher vs. lower 25OHD(3) concentrations (p=0.018). A higher 25OHD(3) concentration had no significant effect on BMD in those receiving placebo.
CONCLUSIONS: Monkeys fed a diet containing 1000 IU/day equivalent of 25OHD(3) have a wide range of plasma 25OHD(3) concentrations. Those receiving CEE with higher 25OHD(3) concentrations had higher BMDs, suggesting 25OHD(3) and CEE have synergistic effects on BMD.
Volume
21
Issue
8
First Page
858
Last Page
864
ISSN
1931-843X
Published In/Presented At
Schnatz, P. F., Marakovits, K. A., O'Sullivan, D. M., Ethun, K., Clarkson, T. B., & Appt, S. E. (2012). Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. Journal of women's health (2002), 21(8), 858–864. https://doi.org/10.1089/jwh.2011.3244
Disciplines
Medicine and Health Sciences
PubMedID
22691032
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article