Age as a predictor of osteoporotic fracture compared with current risk-prediction models.

Publication/Presentation Date

11-1-2013

Abstract

OBJECTIVE: To compare several fracture risk-prediction models and their predictive values.

METHODS: Women older than age 49 years were sent for dual-energy X-ray absorptiometry screening between January 2007 and March 2009. Data collection included multiple osteoporosis risk factors. The ability to identify fractures was analyzed and compared using the North American Menopause Society 2006 and 2010 Position Statements, The Fracture Risk Assessment Tool, along with age alone. The area under the curve (AUC) comparison with chance (AUC 0.50) and paired AUC comparisons between models were used to investigate the efficacy of each model in predicting osteoporotic fractures.

RESULTS: Among the 615 women studied, with mean (standard deviation) age of 61.4 (8.3) years and 94.5% being white, 15 have experienced a fracture. All screening approaches were significantly better than chance at predicting fractures. Paired comparisons of the detection ability of fracture prediction models showed no significant differences. Age alone was a significant predictor for fracture (AUC 0.79, 95% confidence interval [CI] 0.67-0.91, P

CONCLUSION: These data suggest that all current screening modalities are effective in predicting fracture but not significantly better than age alone. Age should be considered carefully while evaluating patients for osteoporosis screening and treatment.

LEVEL OF EVIDENCE: II.

Volume

122

Issue

5

First Page

1040

Last Page

1046

ISSN

1873-233X

Disciplines

Medicine and Health Sciences

PubMedID

24104773

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

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