Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis.
Publication/Presentation Date
8-1-2022
Abstract
OBJECTIVE: The aim of this study is to analyze the association between coronary artery vitamin D receptor (VDR) expression and systemic coronary artery atherosclerosis (CAA) risk factors.
METHODS: Female cynomolgus monkeys (
RESULTS: In postmenopausal monkeys receiving atherogenic diets, serum MCP-1 was significantly elevated compared with baseline (482.2 ± 174.2 pg/ml vs. 349.1 ± 163.2 pg/ml, respectively;
CONCLUSION: Coronary artery VDR expression was inversely correlated with markers of CAA risk and inflammation, including MCP-1, suggesting that systemic and perhaps local inflammation in the artery may be associated with reduced arterial VDR expression.
Volume
25
Issue
4
First Page
369
Last Page
375
ISSN
1473-0804
Published In/Presented At
Nudy, M., Xie, R., O'Sullivan, D. M., Jiang, X., Appt, S., Register, T. C., Kaplan, J. R., Clarkson, T. B., & Schnatz, P. F. (2022). Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis. Climacteric : the journal of the International Menopause Society, 25(4), 369–375. https://doi.org/10.1080/13697137.2021.1985992
Disciplines
Medicine and Health Sciences
PubMedID
34694941
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article