Association between coronary artery vitamin D receptor expression and select systemic risks factors for coronary artery atherosclerosis.

Publication/Presentation Date

8-1-2022

Abstract

OBJECTIVE: The aim of this study is to analyze the association between coronary artery vitamin D receptor (VDR) expression and systemic coronary artery atherosclerosis (CAA) risk factors.

METHODS: Female cynomolgus monkeys (

RESULTS: In postmenopausal monkeys receiving atherogenic diets, serum MCP-1 was significantly elevated compared with baseline (482.2 ± 174.2 pg/ml vs. 349.1 ± 163.2 pg/ml, respectively;

CONCLUSION: Coronary artery VDR expression was inversely correlated with markers of CAA risk and inflammation, including MCP-1, suggesting that systemic and perhaps local inflammation in the artery may be associated with reduced arterial VDR expression.

Volume

25

Issue

4

First Page

369

Last Page

375

ISSN

1473-0804

Disciplines

Medicine and Health Sciences

PubMedID

34694941

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

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