Association of maternal birth weight and maternal preterm birth with subsequent risk for adverse reproductive outcomes: The Women's Health Initiative.

Publication/Presentation Date

9-1-2023

Abstract

BACKGROUND: Advancements in medical technology and pharmacologic interventions have drastically improved survival of infants born preterm and low birth weight, but knowledge regarding the long-term health impacts of these individuals is limited and inconsistent.

AIM: To investigate whether an individual's birthweight or history of being born preterm increases the risk of an adverse reproductive outcome.

STUDY DESIGN: Nested case-control study within the Women's Health Initiative.

SUBJECTS: 79,934 individuals who self-reported their personal birthweight category and/or preterm birth status.

OUTCOMES MEASURES: Self-reported pregnancy outcomes: subfertility, miscarriage, stillbirth, preeclampsia, gestational diabetes, gestational hypertension, preterm birth, low birthweight infant, high birthweight infant. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR).

RESULTS: After adjustments, individuals reporting their birthweight

CONCLUSIONS: As more individuals born preterm and/or low birthweight survive to adulthood, the incidence and prevalence of poor reproductive outcomes may increase. Women born at extremes of birthweight and prematurity may need to be monitored more closely during their own pregnancies.

Volume

184

First Page

105839

Last Page

105839

ISSN

1872-6232

Disciplines

Medicine and Health Sciences

PubMedID

37549575

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

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