BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD.
Publication/Presentation Date
8-27-2024
Abstract
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in
METHODS: To study the interaction between
RESULTS: We first demonstrated that BICC1 physically binds to the proteins Polycystin-1 and -2 encoded by
CONCLUSIONS: These findings support the hypothesis that
ISSN
2692-8205
Published In/Presented At
Tran, U., Streets, A. J., Smith, D., Decker, E., Kirschfink, A., Izem, L., Hassey, J. M., Rutland, B., Valluru, M. K., Bräsen, J. H., Ott, E., Epting, D., Eisenberger, T., Ong, A. C., Bergmann, C., & Wessely, O. (2024). BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD. bioRxiv : the preprint server for biology, 2024.08.27.608867. https://doi.org/10.1101/2024.08.27.608867
Disciplines
Medicine and Health Sciences
PubMedID
39253489
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article