Corticosteroids for enhanced fetal lung maturation in patients with HELLP syndrome: impact on neonates.
Publication/Presentation Date
5-1-1993
Abstract
This study was undertaken to determine retrospectively, in women with the HELLP syndrome, the perinatal effects of corticosteroid administration for promotion of fetal lung maturity. Twenty-seven of 427 women with the HELLP syndrome treated between 1980 and 1991 received a full course of steroids prior to preterm delivery. They were compared to 27 control patients with the HELLP syndrome matched for maternal age, severity of disease, gestational age, race, and sex of the fetus. Respiratory distress requiring mechanical ventilation occurred in 13 of 27 neonates who received steroid administration and in 23 of 27 who did not receive steroids (p < 0.001). The average stay in the neonatal intensive care unit was 29.8 +/- 50.6 days for the steroid-treated group and 45.2 +/- 35.3 days for the group without steroid use (p = NS). The incidence of neonatal deaths, intraventricular haemorrhage type III and IV, necrotizing enterocolitis, and retrolental fibroplasia was greater in the control group but the difference was not statistically significant.
Volume
33
Issue
2
First Page
131
Last Page
135
ISSN
0004-8666
Published In/Presented At
Magann, E. F., Graves, G. R., Roberts, W. E., Blake, P. G., Morrison, J. C., & Martin, J. N., Jr (1993). Corticosteroids for enhanced fetal lung maturation in patients with HELLP syndrome: impact on neonates. The Australian & New Zealand journal of obstetrics & gynaecology, 33(2), 131–135. https://doi.org/10.1111/j.1479-828x.1993.tb02375.x
Disciplines
Medicine and Health Sciences
PubMedID
8216108
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article