Immunohistochemical localization of gonadotropin-releasing hormone during implantation in the New Zealand white rabbit.
Publication/Presentation Date
4-1-1991
Abstract
Gonadotropin-releasing hormone was localized immunohistochemically during implantation (gestational days 6 to 14) in the New Zealand White rabbit. During early implantation (days 7 to 9), intense gonadotropin-releasing hormone immunostaining was localized predominantly to the cytoplasm of the nonknob cytotrophoblast with light to moderate staining in the cytoplasm of the syncytiotrophoblast (knob). In later gestation, light to moderate staining of the cytoplasm of the trophoblast at the true placental site was detected. No appreciable change in staining was noted after day 10. Fetal membranes, identified after day 10, showed intense and unchanging immunostaining for gonadotropin-releasing hormone. Obplacental giant cells showed light to moderate nuclear and cytoplasmic gonadotropin-releasing hormone immunostaining. Light to moderate gonadotropin-releasing hormone immunostaining was also noted in the cytoplasm of uterine epithelium and glands. We conclude that immunoreactive gonadotropin-releasing hormone is present in the cytotrophoblast at the time of the earliest embryo-uterine interactions and may play a significant role in implantation and embryo survival.
Volume
164
Issue
4
First Page
1127
Last Page
1131
ISSN
0002-9378
Published In/Presented At
Bergh, P. A., Anderson, T. L., & Hofmann, G. E. (1991). Immunohistochemical localization of gonadotropin-releasing hormone during implantation in the New Zealand white rabbit. American journal of obstetrics and gynecology, 164(4), 1127–1131. https://doi.org/10.1016/0002-9378(91)90600-v
Disciplines
Medicine and Health Sciences
PubMedID
1707595
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article