Basal antral follicle number and mean ovarian diameter predict cycle cancellation and ovarian responsiveness in assisted reproductive technology cycles.

Publication/Presentation Date

9-1-2000

Abstract

OBJECTIVE: To determine the predictive value and define threshold levels for basal antral follicle number and mean ovarian diameter in patients undergoing ART cycles.

DESIGN: Retrospective.

SETTING: Tertiary care center.

PATIENTS: Two hundred seventy-eight patients who had ovarian measurements performed on cycle day 3 before beginning treatment with gonadotropins.

INTERVENTION: Pretreatment ovarian ultrasound measurements.

MAIN OUTCOME MEASURE: Number of oocytes retrieved, hormone levels, and cycle outcomes.

RESULTS: A direct linear correlation was observed between mean ovarian diameter and basal follicle number. Both measures demonstrated a positive linear correlation with recovered oocytes, basal E(2), and peak E(2). Both demonstrated a negative linear correlation with ampules of gonadotropins administered, days of stimulation, patient age, cycle day 3 FSH, and FSH:LH ratio. An antral follicle count of

CONCLUSIONS: Ovarian diameter and basal antral follicle number identify patients who may respond poorly to ART stimulation. These ovarian measures correlate well with ART screening and stimulation parameters. This knowledge allows physicians to evaluate and counsel patients immediately before an ART stimulation and to optimize stimulation protocols.

Volume

74

Issue

3

First Page

512

Last Page

517

ISSN

0015-0282

Disciplines

Medicine and Health Sciences

PubMedID

10973648

Department(s)

Department of Obstetrics and Gynecology

Document Type

Article

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