Response of Human Fetal Liver Progenitor Cell Types to Temperature and pH Stresses In Vitro.
Publication/Presentation Date
6-1-2018
Abstract
Prolonged physiological stresses, including abnormal pH and temperature, are deleterious. However, human hepatic progenitors have been shown to be quite tolerant of temporary temperature stress such as in cold ischemia. We aimed at identifying how various stresses affect liver progenitors, and at determining whether distinct effects exist on different progenitor cells of the human liver. Total fetal liver cells were exposed to low (25°C), normal (37°C), or high (40°C) temperatures, or low (6.76), normal (7.35), or high (7.88) pH in vitro. Culture at 25°C increased cell numbers and percentages of proliferation marker Ki67
Volume
21
Issue
3
First Page
257
Last Page
269
ISSN
1557-8577
Published In/Presented At
Schmelzer, E., Foka, H. G., Thompson, R. L., Luca, A., Gridelli, B., & Gerlach, J. C. (2018). Response of Human Fetal Liver Progenitor Cell Types to Temperature and pH Stresses In Vitro. Rejuvenation research, 21(3), 257–269. https://doi.org/10.1089/rej.2016.1890
Disciplines
Medicine and Health Sciences
PubMedID
28891399
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article