The administration of chemotherapy in a patient with Charcot-Marie-Tooth and ovarian cancer.
Publication/Presentation Date
5-1-2005
Abstract
BACKGROUND: Standard adjuvant chemotherapy for epithelial ovarian carcinoma most commonly consists of a combination of carboplatin with a taxane derivative. However, treatment-related side effects such as peripheral neuropathy and neutropenia can be debilitating and in certain patient populations alterations may need to be considered.
CASE: We describe a case of a patient with epithelial ovarian carcinoma who had pre-existing peripheral neuropathy secondary to Charcot-Marie-Tooth Disease (CMT). She developed a distal sensory and motor neuropathy after her first treatment with carboplatin and paclitaxel and was unable to walk, write, or drive. Upon transfer of care to our center, we changed her taxane to docetaxel and her symptoms improved dramatically. We discuss the outcome of her treatment and the effects of paclitaxel on her underlying peripheral neuropathy.
CONCLUSION: Patients with Charcot-Marie-Tooth Disease who require chemotherapy may not be able to tolerate the neurotoxic side effects of paclitaxel-based chemotherapy. Consideration of alternative, less neurotoxic treatment regimens containing docetaxel may be considered.
Volume
97
Issue
2
First Page
710
Last Page
712
ISSN
0090-8258
Published In/Presented At
Martino, M. A., Miller, E., & Grendys, E. J. (2005). The administration of chemotherapy in a patient with Charcot-Marie-Tooth and ovarian cancer. Gynecologic Oncology, 97(2), 710-712.
Disciplines
Obstetrics and Gynecology
PubMedID
15863189
Department(s)
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty
Document Type
Article