Preeclampsia: Immunologic Alteration of Nitabuch's Membrane? Clinical Sequelae.
Publication/Presentation Date
11-1-1997
Abstract
OBJECTIVE: To determine if preeclampsia is an immunologic disease process consistent with a host-vs.-graft reaction by examining differences in immunoglobulin deposition at the maternal fetal interface (Nitabuch's layer) in preeclamptic patients.
STUDY DESIGN: A prospective study of patients at Lehigh Valley Hospital was conducted between July 1993 and April 1994. Group 1 (study) consisted of 11 primigravid women meeting the criteria for the diagnosis of preeclampsia. Group 2 (control) consisted of 11 primigravid women who had an uncomplicated pregnancy. At delivery, basal plate placental specimens were obtained, fixed, and processed for study by a blinded observer utilizing IgG, IgA, IgM, IgE immunofluorescence techniques. The placenta was then sent to a gynecologic pathologist for blinded evaluation and measurement of Nitabuch's membrane by light microscopy.
RESULTS: Taking the average width of 3 measurements of Nitabuch's membrane by light microscopy revealed no significant difference (group 1, .1839 mm vs. group 2, .1555 mm). Immunofluorescence techniques revealed that the thickness of immunofluorescence of Nitabuch's membrane was significantly greater in the study group vs. the control group (157.48 pixels vs. 63.80 pixels, P = .006, respectively).
CONCLUSION: Evaluation of the maternal-fetal interface reveals the deposition of increased immunoglobulins, the physiology of which may be similar to nephropathies as seen in systemic disease processes. The deposition of immunoglobulins may be associated with a common antigen which may point to an immunologic etiology for preeclampsia in some women.
Volume
6
Issue
6
First Page
324
Last Page
328
ISSN
1057-0802
Published In/Presented At
Balducci, J., Weiss, P. M., Atlas, R. O., Pajarillo, M. F., Dupree, W. B., & Klasko, S. K. (1997). Preeclampsia: immunologic alteration of Nitabuch's membrane? Clinical sequelae. The Journal Of Maternal-Fetal Medicine, 6(6), 324-328.
Disciplines
Obstetrics and Gynecology
PubMedID
9438214
Department(s)
Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Faculty
Document Type
Article