Mesenchymal stem cell therapies in brain disease.
Publication/Presentation Date
11-1-2019
Abstract
As treatments for diseases throughout the body progress, treatment for many brain diseases has been at a standstill due to difficulties in drug delivery. While new drugs are being discovered in vitro, these therapies are often hindered by inefficient tissue distribution and, more commonly, an inability to cross the blood brain barrier. Mesenchymal stem cells are thus being investigated as a delivery tool to directly target therapies to the brain to treat wide array of brain diseases. This review discusses the use of mesenchymal stem cells in hypoxic disease (hypoxic ischemic encephalopathy), an inflammatory neurodegenerative disease (multiple sclerosis), and a malignant condition (glioma).
Volume
95
First Page
111
Last Page
119
ISSN
1096-3634
Published In/Presented At
Sherman, L. S., Romagano, M. P., Williams, S. F., & Rameshwar, P. (2019). Mesenchymal stem cell therapies in brain disease. Seminars in cell & developmental biology, 95, 111–119. https://doi.org/10.1016/j.semcdb.2019.03.003
Disciplines
Medicine and Health Sciences
PubMedID
30922957
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article