Treatment modalities in recurrent miscarriages without diagnosis.
Publication/Presentation Date
7-1-2014
Abstract
Recurrent miscarriage is defined as the loss of three consecutive pregnancies before 20 weeks' gestational age. Patients are referred to subspecialists such as reproductive endocrinology or maternal fetal medicine to exclude the most common causes of recurrent miscarriage including autoimmune disorders, structural uterine pathology, metabolic derangements, hematologic conditions, and chromosomal abnormalities. Unfortunately, this extensive list of conditions accounts for less than 50% of patients affected by recurrent miscarriage, leaving the remaining 50% without answers. Multiple treatment modalities, including supplementation with progesterone, human chorionic gonadotropin, aspirin with and without heparin, and immune modulators have been tested for this large percentage of patients with very few answers. In fact, the only successful intervention addressed in the literature consists of supportive care at a dedicated recurrent miscarriage clinic. Without large randomized clinical trials, there is no evidence to support the use of supplemental medications in this patient population.
Volume
32
Issue
4
First Page
319
Last Page
322
ISSN
1526-4564
Published In/Presented At
Whitley, K. A., & Ural, S. H. (2014). Treatment modalities in recurrent miscarriages without diagnosis. Seminars in reproductive medicine, 32(4), 319–322. https://doi.org/10.1055/s-0034-1375185
Disciplines
Medicine and Health Sciences
PubMedID
24919032
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article