Functional selectivity in adrenergic and angiotensin signaling systems.
Publication/Presentation Date
12-1-2010
Abstract
β-Adrenergic and angiotensin II type 1A receptors are therapeutic targets for the treatment of a number of common human diseases. Pharmacological agents designed as antagonists for these receptors have positively affected the morbidity and mortality of patients with hypertension, heart failure, and renal disease. Antagonism of these receptors, however, may only partially explain the therapeutic benefits of β-blockers and angiotensin receptor blockers given the emerging concept of functional selectivity or biased agonism. This new pharmacological paradigm suggests that multiple signaling pathways can be differentially modified by a single ligand-receptor interaction. This review examines the functional selectivity of β-adrenergic and angiotensin II type 1A receptors with respect to their ability to signal via both G protein-dependent and G protein-independent mechanisms, with a focus on the multifunctional protein β-arrestin. Also highlighted are the concept of "biased signaling" through β-arrestin mediated pathways, the affect of ligand/receptor modification on such biased agonism, and the implications of functional selectivity for the development of the next generation of β-blockers and angiotensin receptor blockers.
Volume
78
Issue
6
First Page
983
Last Page
992
ISSN
1521-0111
Published In/Presented At
Patel, C. B., Noor, N., & Rockman, H. A. (2010). Functional selectivity in adrenergic and angiotensin signaling systems. Molecular pharmacology, 78(6), 983–992. https://doi.org/10.1124/mol.110.067066
Disciplines
Medicine and Health Sciences
PubMedID
20855464
Department(s)
Department of Obstetrics and Gynecology
Document Type
Article