Synthesis of β-substituted tryptamines by regioselective ring opening of aziridines.

Publication/Presentation Date

6-30-2016

Abstract

Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful method for tryptamine synthesis if site selectivity can be controlled. 4-Nitrobenzyl carbamate (PNZ)-protected aziridines undergo regioselective ring opening to produce β-substituted tryptamines for a series of indoles. The PNZ-protected tryptamines can be further manipulated by PNZ removal under mild conditions.

Volume

72

Issue

26

First Page

3802

Last Page

3807

ISSN

0040-4020

Disciplines

Medicine and Health Sciences

PubMedID

27378819

Department(s)

Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology Residents, Fellows and Residents

Document Type

Article

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