Glioblastoma Multiforme in the Muir-Torre Syndrome.
Publication/Presentation Date
6-1-2011
Abstract
Muir-Torre syndrome (MTS) is an autosomal dominant subtype of nonpolyposis colorectal carcinoma (HNPCC) characterized by the development of sebaceous gland tumors and visceral malignancies. The most common subtype of MTS is characterized by germline mutations in mismatch repair (MMR) genes leading to microsatellite instability (MSI). Central nervous system tumors have only rarely been associated with MTS. In this report, we describe the development of a glioblastoma multiforme (GBM) in a patient with MTS. Immunohistochemical analysis of the patient's colon carcinoma and his GBM both revealed loss of the mismatch repair proteins mutS homolog 2 (MSH2) and mutS homolog 6 (MSH6).
Volume
113
Issue
5
First Page
411
Last Page
415
ISSN
1872-6968
Published In/Presented At
Binder, Z. A., Johnson, M. W., Joshi, A., Hann, C. L., Griffin, C. A., Olivi, A., & ... Gallia, G. L. (2011). Glioblastoma multiforme in the Muir-Torre syndrome. Clinical Neurology And Neurosurgery, 113(5), 411-415. doi:10.1016/j.clineuro.2010.12.011
Disciplines
Medical Pathology | Pathology
PubMedID
21288634
Peer Reviewed for front end display
Peer-Reviewed
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article