Rapid Malignant Transformation of Low-Grade Astrocytomas: Report of 2 Cases and Review of the Literature.
BACKGROUND: Low-grade gliomas have been documented to undergo transformation into high-grade astrocytomas, and the time interval of this transformation has been reported to generally occur within 5 years in about 50% of patients harboring these low-grade lesions. Several studies have investigated the evolution of low-grade gliomas into malignant gliomas by CT and MRI characteristics, but many have not documented the timing of these transformation processes.
CASE DESCRIPTION: The authors discuss the cases of 2 patients with histopathologically confirmed grade II astrocytomas after craniotomies that underwent rapid evolution into malignant gliomas within 13 weeks. Interestingly, both low-grade astrocytomas were positive with immunostaining for the epidermal growth factor receptor, in which its amplification has been implicated as a molecular marker of malignant gliomas. In addition, the grade II astrocytomas were negative for p53 in both patients but were found to be positive upon transformation into malignant gliomas.
CONCLUSIONS: To our knowledge, this is the first report of rapid malignant transformation of low-grade gliomas, which were proven by histology, within 13 weeks. There may be patients with a subtype of low-grade astrocytomas that may warrant molecular characterization to determine if aggressive adjuvant therapy would be of benefit.
Published In/Presented At
Frazier, J. L., Johnson, M. W., Burger, P. C., Weingart, J. D., & Quinones-Hinojosa, A. (2010). Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World Neurosurgery, 73(1), 53. doi:10.1016/j.surneu.2009.05.010
Medical Pathology | Pathology
Peer Reviewed for front end display
Department of Pathology and Laboratory Medicine