Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study.
Publication/Presentation Date
3-29-2010
Abstract
The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance images (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logistic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36 girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6 promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71-26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 - 26.0]. No associations were observed among boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.
Volume
1
Issue
2
First Page
158
Last Page
165
ISSN
1948-1756
Published In/Presented At
Eskola, P. J., Kjaer, P., Daavittila, I. M., Solovieva, S., Okuloff, A., Sorensen, J. S., Wedderkopp, N., Ala-Kokko, L., Männikkö, M., & Karppinen, J. I. (2010). Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study. International journal of molecular epidemiology and genetics, 1(2), 158–165.
Disciplines
Medicine and Health Sciences
PubMedID
21537388
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article