Primary intracranial atypical teratoid/rhabdoid tumor in a child with Canavan disease.
Publication/Presentation Date
1-1-1995
Abstract
A primary intracranial atypical teratoid/rhabdoid tumor was encountered in a child (age 4 years and 9 months) with Canavan disease. The tumor contained a large spindled cell component as well as classical rhabdoid morphology and focal areas resembling a primitive neuroectodermal tumor. The rhabdoid areas of the neoplasm were immunoreactive with antibodies against epithelial membrane antigen and vimentin, in the classically described pattern. Ultrastructurally these portions of the tumor displayed the characteristic perinuclear whorls of intermediate filaments reported in rhabdoid tumors of all body sites. Thought to be purely coincidental, this is also the first description of any intracranial neoplasm associated with Canavan disease.
Volume
22
Issue
4
First Page
214
Last Page
222
ISSN
1016-2291
Published In/Presented At
Manhoff, D. T., Rorke, L. B., & Yachnis, A. T. (1995). Primary intracranial atypical teratoid/rhabdoid tumor in a child with Canavan disease. Pediatric neurosurgery, 22(4), 214–222. https://doi.org/10.1159/000120904
Disciplines
Medicine and Health Sciences
PubMedID
7619723
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article