Translocation (X;20)(q13.1;q13.3) as a Primary Chromosomal Finding in Two Patients with Myelocytic Disorders.
Publication/Presentation Date
3-1-2003
Abstract
Reports of X chromosome translocations, as primary chromosomal changes associated with hematologic disorders, remain relatively uncommon. Herein, we report the detection, by conventional cytogenetic methods, of a cytogenetically identical t(X;20) in two different patients with hematologic disorders (probable myelodysplasia and polycythemia vera/acute myelocytic leukemia). In both cases, this translocation appeared as the primary clonal chromosome abnormality, with breakpoints occurring in the long arms of both the X chromosome and chromosome 20 (Xq13.1 and 20q13.3, respectively). Further characterization and comparison of the translocation chromosome products of these two cases by use of fluorescence in situ hybridization techniques is also described. Similar previously reported cytogenetically cases and the potential that this specific rearrangement may represent a nonrandom chromosomal finding are discussed.
Volume
141
Issue
2
First Page
169
Last Page
174
ISSN
0165-4608
Published In/Presented At
Gray, B. A., Cornfield, D., Bent-Williams, A., & Zori, R. T. (2003). Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders. Cancer Genetics And Cytogenetics, 141(2), 169-174.
Disciplines
Medical Pathology | Pathology
PubMedID
12606138
Department(s)
Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty
Document Type
Article