Preventive effect of malotilate on dimethylnitrosamine-induced liver fibrosis in the rat.

Publication/Presentation Date

2-1-1989

Abstract

Dimethylnitrosamine-induced liver damage, which leads to hepatic failure and death of the animal, was prevented by treatment with malotilate. The accumulation of collagen and the morphologic changes caused by dimethylnitrosamine, such as inflammatory cell accumulation and fibrosis, were also prevented by this drug. Malotilate drastically reduced the increases in the amount of type I procollagen alpha 2-chain mRNA and activities of the enzymes prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, which are early events in liver fibrosis preceding the deposition of collagen. Even when started 14 days after dimethylnitrosamine induction, malotilate treatment was able to reduce liver damage. We suggest that the effect of malotilate is a result of the inhibition of inflammation.

Volume

113

Issue

2

First Page

177

Last Page

183

ISSN

0022-2143

Disciplines

Medicine and Health Sciences

PubMedID

2915182

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article

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