Scleredema and paraproteinemia. Enhanced collagen production and elevated type I procollagen messenger RNA level in fibroblasts grown from cultures from the fibrotic skin of a patient.
Publication/Presentation Date
2-1-1987
Abstract
An edematous rash developed on the abdominal skin of a 76-year-old woman who had had diabetes mellitus for ten years. Some months later, the affected skin became thickened and indurated. Histopathologic examination revealed marked dermal fibrosis with excessive deposition of collagen. The patient also had IgA (k-type) paraproteinemia. Fibroblast cultures from the affected and unaffected skin were studied for collagen metabolism. Procollagen synthesis was elevated about sixfold on fibroblasts derived from the affected skin. A similar increase was detected in messenger RNA (mRNA) levels using a complementary DNA clone specific for human pro alpha 1(l) collagen mRNA. The elevated mRNA level could be the result of increased transcriptional activity of collagen genes or decreased degradation of collagen mRNAs. Our findings suggest that increased collagen deposition may account for the marked dermal fibrosis that we observed in this patient.
Volume
123
Issue
2
First Page
226
Last Page
229
ISSN
0003-987X
Published In/Presented At
Oikarinen, A., Ala-Kokko, L., Palatsi, R., Peltonen, L., & Uitto, J. (1987). Scleredema and paraproteinemia. Enhanced collagen production and elevated type I procollagen messenger RNA level in fibroblasts grown from cultures from the fibrotic skin of a patient. Archives of dermatology, 123(2), 226–229. https://doi.org/10.1001/archderm.123.2.226
Disciplines
Medicine and Health Sciences
PubMedID
3813596
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article