HO-1
Publication/Presentation Date
4-5-2018
Abstract
Patients with sickle cell disease (SCD) suffer from intravascular hemolysis associated with vascular injury and dysfunction in mouse models, and painful vaso-occlusive crisis (VOC) involving increased attachment of sickle erythrocytes and activated leukocytes to damaged vascular endothelium. Patrolling monocytes, which normally scavenge damaged cells and debris from the vasculature, express higher levels of anti-inflammatory heme oxygenase 1 (HO-1), a heme degrading enzyme. Here, we show that HO-1-expressing patrolling monocytes protect SCD vasculature from ongoing hemolytic insult and vaso-occlusion. We found that a mean 37% of patrolling monocytes from SCD patients express very high levels of HO-1 (HO-1
Volume
131
Issue
14
First Page
1600
Last Page
1610
ISSN
1528-0020
Published In/Presented At
Liu, Y., Jing, F., Yi, W., Mendelson, A., Shi, P., Walsh, R., Friedman, D. F., Minniti, C., Manwani, D., Chou, S. T., & Yazdanbakhsh, K. (2018). HO-1hi patrolling monocytes protect against vaso-occlusion in sickle cell disease. Blood, 131(14), 1600–1610. https://doi.org/10.1182/blood-2017-12-819870
Disciplines
Medicine and Health Sciences
PubMedID
29437594
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article