Differentiation of regulatory myeloid and T-cells from adult human hematopoietic stem cells after allogeneic stimulation.
Publication/Presentation Date
1-1-2024
Abstract
INTRODUCTION: Donor hematopoietic stem cell (DHSC) infusions are increasingly being studied in transplant patients for tolerance induction.
METHODS: To analyze the fate of infused DHSCs in patients, we developed an
RESULTS: Flow cytometric analyses revealed loss of the CD34 marker and an increase in CD33
DISCUSSION: Extrapolation of these results into the clinical situation would suggest that DHSC infusions into transplant recipients may generate multiple subsets of donor "chimeric" cells and promote recipient Treg development that could regulate the anti-donor immune response in the periphery. These studies have also indicated that T cell maturation can occur
Volume
15
First Page
1366972
Last Page
1366972
ISSN
1664-3224
Published In/Presented At
Mathew, J. M., Sanders, J. M., Cirocco, R., Miller, J., & Leventhal, J. R. (2024). Differentiation of regulatory myeloid and T-cells from adult human hematopoietic stem cells after allogeneic stimulation. Frontiers in immunology, 15, 1366972. https://doi.org/10.3389/fimmu.2024.1366972
Disciplines
Medicine and Health Sciences
PubMedID
38455047
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article