Sensitivity of detection of B-cell lymphoma in bone marrow by fluorescence in situ hybridization.
Publication/Presentation Date
10-15-2002
Abstract
Fluorescence in situ hybridization (FISH) was used in a retrospective study of bone marrow aspirate specimens submitted for conventional cytogenetic analysis with an indication of B-cell lymphoma. About 50% of cytogenetically normal samples, which had been identified as containing lymphoma by pathology, showed small cell populations with an IGH gene rearrangement by FISH. This study demonstrates that FISH scoring of 750 nuclei provides a 99% chance of identifying the presence of lymphoma with a 14q32 aberration when this population constitutes approximately 8% of the bone marrow.
Volume
138
Issue
2
First Page
174
Last Page
176
ISSN
0165-4608
Published In/Presented At
Juenger, C., & Stanley, W. S. (2002). Sensitivity of detection of B-cell lymphoma in bone marrow by fluorescence in situ hybridization. Cancer genetics and cytogenetics, 138(2), 174–176. https://doi.org/10.1016/s0165-4608(02)00569-1
Disciplines
Medicine and Health Sciences
PubMedID
12505267
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article