Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia.
Publication/Presentation Date
8-6-2008
Abstract
Adrenocorticotropic hormone (ACTH) is involved in systemic reactions to stress. The aim of the present study was a comprehensive analysis of serum and cerebrospinal fluid (CSF) levels of ACTH, and the pituitary immunohistochemistry with special regard to fatal hypothermia in routine forensic autopsy cases (n=162: 5-97 years of age; 114 males and 48 females; 4 h to 3 days postmortem, median, 19.2 h). The ACTH concentrations were independent of the postmortem time, gender, or age of the subjects. The serum ACTH level was similar to the clinical reference value for sharp instrument injury, fire fatality, and hypothermia, but was lower in other groups including hyperthermia, in particular for asphyxia and poisoning. The CSF level was usually much higher than the serum level, but was significantly lower for hypothermia and hyperthermia than in other groups (p
Volume
179
Issue
2-3
First Page
147
Last Page
151
ISSN
1872-6283
Published In/Presented At
Ishikawa, T., Quan, L., Li, D. R., Zhao, D., Michiue, T., Hamel, M., & Maeda, H. (2008). Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia. Forensic science international, 179(2-3), 147–151. https://doi.org/10.1016/j.forsciint.2008.04.023
Disciplines
Medicine and Health Sciences
PubMedID
18554831
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article