Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types.
Publication/Presentation Date
10-1-2004
Abstract
C2C12 myoblasts expressing the androgen receptor (AR) were used to analyze the role of androgen-AR signaling pathway in skeletal muscle development. Marked up-regulation of AR expression was observed in differentiated myotubes. A nuclear run-on transcription assay demonstrated that transcription of the AR gene is increased during skeletal muscle cell differentiation. Regulation of skeletal muscle-specific protein expression by the androgen-AR signaling pathway was further analyzed using quadriceps skeletal muscle from wild-type (WT) and AR knock-out (ARKO) male mice. A histological analysis of quadriceps skeletal muscle indicates no morphological differences between ARKO and WT mice. However, the androgen-AR signaling pathway increases expression of slow-twitch-specific skeletal muscle proteins and downregulates fast-twitch-specific skeletal muscle proteins, resulting in an increase of slow-twitch muscle fiber type cells in quadriceps muscle.
Volume
25
Issue
1
First Page
27
Last Page
32
ISSN
1355-008X
Published In/Presented At
Altuwaijri, S., Lee, D. K., Chuang, K. H., Ting, H. J., Yang, Z., Xu, Q., Tsai, M. Y., Yeh, S., Hanchett, L. A., Chang, H. C., & Chang, C. (2004). Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types. Endocrine, 25(1), 27–32. https://doi.org/10.1385/endo:25:1:27
Disciplines
Medicine and Health Sciences
PubMedID
15545703
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article