Impact of Vasectomy on the Development and Progression of Prostate Cancer: Preclinical Evidence.

Authors

Takashi Kawahara
Yuki Teramoto
Yi Li
Hitoshi Ishiguro
Jennifer Gordetsky
Zhi-Ming Yang MD, PhD, Lehigh Valley Health NetworkFollow
Hiroshi Miyamoto

Publication/Presentation Date

8-15-2020

Abstract

Some observational studies have implied a link between vasectomy and an elevated risk of prostate cancer. We investigated the impact of vasectomy on prostate cancer outgrowth, mainly using preclinical models. Neoplastic changes in the prostate were compared in transgenic TRAMP mice that underwent vasectomy vs. sham surgery performed at 4 weeks of age. One of the molecules identified by DNA microarray (i.e., ZKSCAN3) was then assessed in radical prostatectomy specimens and human prostate cancer lines. At 24 weeks, gross tumor (

Volume

12

Issue

8

ISSN

2072-6694

Published In/Presented At

Kawahara, T., Teramoto, Y., Li, Y., Ishiguro, H., Gordetsky, J., Yang, Z., & Miyamoto, H. (2020). Impact of Vasectomy on the Development and Progression of Prostate Cancer: Preclinical Evidence. Cancers, 12(8), 2295. https://doi.org/10.3390/cancers12082295

Disciplines

Medicine and Health Sciences

PubMedID

32824199

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article