Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Publication/Presentation Date
11-1-2019
Abstract
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including
Volume
8
ISSN
2050-084X
Published In/Presented At
Bhagat, T. D., Von Ahrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Aluri, S., Bhattacharyya, S., Sahu, S., Bhagat, P., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., … Verma, A. (2019). Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts. eLife, 8, e50663. https://doi.org/10.7554/eLife.50663
Disciplines
Medicine and Health Sciences
PubMedID
31663852
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article