Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis.

Authors

Pragnya Das
Santosh K Panda
Beamon Agarwal MD, PhD, Lehigh Valley Health NetworkFollow
Sumita Behera
Syed M Ali
Mark E Pulse
Joseph S Solomkin
Steven M Opal
Vineet Bhandari
Suchismita Acharya

Publication/Presentation Date

2-27-2019

Abstract

In Gram-negative bacterial sepsis, production of excess pro-inflammatory cytokines results in hyperinflammation and tissue injury. Anti-inflammatory cytokines such as IL-10 inhibit inflammation and enhance tissue healing. Here, we report a novel approach to treat septicemia associated with intra-abdominal infection in a murine model by delicately balancing pro- and anti-inflammatory cytokines. A novel oligosaccharide compound AVR-25 selectively binds to the TLR4 protein (IC

Volume

9

Issue

1

First Page

2904

Last Page

2904

ISSN

2045-2322

Published In/Presented At

Das, P., Panda, S. K., Agarwal, B., Behera, S., Ali, S. M., Pulse, M. E., Solomkin, J. S., Opal, S. M., Bhandari, V., & Acharya, S. (2019). Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Scientific reports, 9(1), 2904. https://doi.org/10.1038/s41598-019-38731-3

Disciplines

Medicine and Health Sciences

PubMedID

30814582

Department(s)

Department of Pediatrics

Document Type

Article