Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits.
Publication/Presentation Date
1-1-2020
Abstract
BACKGROUND: Invasive mechanical ventilation (IMV) has become one of the mainstays of therapy in NICUs worldwide, as a result of which premature babies with extremely low birth weight have been able to survive. Although lifesaving, IMV can result in lung inflammation and injury. Surfactant therapy is considered a standard of care in preterm infants with immature lungs. Recently, small molecule inhibitors like siRNAs and miRNAs have been used for therapeutic purposes. Ddit3 (CHOP), Ang2 and miR34a are known to be upregulated in experimental lung injury. We wanted to test whether inhibitors for these molecules (CHOP siRNA, Ang2 siRNA, and miR34a antagomir) if used alone or with a combination with surfactant (Curosurf
METHODS: Preterm rabbits born by cesarean section were intratracheally instilled with the three small molecule inhibitors with or without Curosurf
RESULTS: Our data shows that Curosurf
CONCLUSION: Our study shows that Curosurf
Volume
11
First Page
266
Last Page
266
ISSN
1664-042X
Published In/Presented At
Das, P., Curstedt, T., Agarwal, B., Prahaladan, V. M., Ramirez, J., Bhandari, S., Syed, M. A., Salomone, F., Casiraghi, C., Pelizzi, N., & Bhandari, V. (2020). Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits. Frontiers in physiology, 11, 266. https://doi.org/10.3389/fphys.2020.00266
Disciplines
Medicine and Health Sciences
PubMedID
32327998
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article