Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Publication/Presentation Date
5-23-2022
Abstract
Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin-1 receptor accessory protein (IL1RAP) is an innate immune mediator that regulates activation of pro-inflammatory and mitogenic signaling pathways. Immunohistochemistry on tissue microarrays demonstrated expression of IL1RAP in majority of human PDAC specimens and in murine pancreatic tumors from K-Ras
Volume
15
Issue
1
First Page
70
Last Page
70
ISSN
1756-8722
Published In/Presented At
Zhang, Y., Chen, X., Wang, H., Gordon-Mitchell, S., Sahu, S., Bhagat, T. D., Choudhary, G., Aluri, S., Pradhan, K., Sahu, P., Carbajal, M., Zhang, H., Agarwal, B., Shastri, A., Martell, R., Starczynowski, D., Steidl, U., Maitra, A., & Verma, A. (2022). Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer. Journal of hematology & oncology, 15(1), 70. https://doi.org/10.1186/s13045-022-01286-4
Disciplines
Medicine and Health Sciences
PubMedID
35606824
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article