Establishing Absolute Lymphocyte Count Thresholds for Further Review of Peripheral Blood Lymphocytosis to Judiciously Screen for Monoclonal B-Cell Populations in Older Adults.
Publication/Presentation Date
9-9-2019
Abstract
OBJECTIVES: Lymphocytosis may represent either a lymphoproliferative disorder (LPD) or a reactive process. The absolute lymphocyte count (ALC) threshold for further evaluation of lymphocytosis is not well established.
METHODS: We prospectively performed flow cytometry on blood samples from patients 50 years or older with ALCs of 4.0 × 109 cells/L or greater without a history of an LPD.
RESULTS: Monoclonal B-cell populations were found in 34 (19.1%) of 178 cases, with incidence increasing with age. In patients younger than 75 years, no monoclonal B-cell population was identified in patients with ALCs less than 4.4 × 109 cells/L, while such clones were found below and above this threshold in patients 75 years and older.
CONCLUSIONS: These findings support a threshold for smear review and flow cytometry no lower than 4.4 × 109 cells/L in patients younger than 75 years and a threshold as low as 4.0 × 109 cells/L in patients 75 years and older.
Volume
152
Issue
4
First Page
458
Last Page
462
ISSN
1943-7722
Published In/Presented At
Muscara, M. J., Cook, B. A., Dhesi, M. S., Groo, S. C., & Andrews, J. M. (2019). Establishing Absolute Lymphocyte Count Thresholds for Further Review of Peripheral Blood Lymphocytosis to Judiciously Screen for Monoclonal B-Cell Populations in Older Adults. American journal of clinical pathology, 152(4), 458–462. https://doi.org/10.1093/ajcp/aqz057
PubMedID
31165137
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article