Granulomatous secondary syphilis: Another diagnostic pitfall for the dermatopathologist.
Publication/Presentation Date
3-1-2023
Abstract
Syphilis is growing ever more prevalent in the United States with its incidence rising every year. Dermatopathologists need to maintain a high index of suspicion to avoid delayed diagnosis of this treatable disease. Accordingly, it is imperative to be aware of its myriad of presentations-including secondary syphilis with granulomatous inflammation. Most cases show aggregations of epithelioid histiocytes associated with plasma cells. Other patterns include an interstitial granuloma-annulare-like pattern, sarcoidal, and tuberculoid pattern. Immunohistochemical stains for Treponema pallidum may be negative, especially in late secondary or tertiary syphilis. We present a case of nodular secondary syphilis with granulomatous inflammation with negative T. pallidum staining.
Volume
50
Issue
3
First Page
209
Last Page
212
ISSN
1600-0560
Published In/Presented At
Jin, A., McLarney, B. D., Hsu, S., & Lee, J. B. (2023). Granulomatous secondary syphilis: Another diagnostic pitfall for the dermatopathologist. Journal of cutaneous pathology, 50(3), 209–212. https://doi.org/10.1111/cup.14370
Disciplines
Medicine and Health Sciences
PubMedID
36437794
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article