Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease.

Authors

Christina W Sun
Shoshana K Grossman
Rodrigo Valdes-Rodriguez
Jason B. Lee, MD, Thomas Jefferson UniversityFollow
Sylvia Hsu

Publication/Presentation Date

1-15-2020

Abstract

A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as "guttate leukoderma," this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf.

Volume

26

Issue

1

ISSN

1087-2108

Published In/Presented At

Sun, C. W., Grossman, S. K., Valdes-Rodriguez, R., Lee, J. B., & Hsu, S. (2020). Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease. Dermatology online journal, 26(1), 13030/qt5938q4rj.

Disciplines

Medicine and Health Sciences

PubMedID

32155025

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article