Mixed pancreatic ductal adenocarcinoma and well-differentiated neuroendocrine tumor: A case report.

Publication/Presentation Date

12-15-2024

Abstract

BACKGROUND: Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas. The World Health Organization defines MiNENs as neoplasms composed of morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting 30% or more of the tumor volume. Adenocarcinoma-neuroendocrine carcinoma is the most frequent MiNEN combination. A well-differentiated neuroendocrine tumor (NET) component is rarely reported in MiNENs.

CASE SUMMARY: Here we report a rare case with intermingled components of ductal adenocarcinoma and grade 1 well-differentiated NET in the pancreas. The two tumors show distinct histology and significant differentiation discrepancy (poorly differentiated high grade adenocarcinoma and well-differentiated low grade NET), and also present as metastases in separate lymph nodes. Next generation sequencing of the two components demonstrates

CONCLUSION: Mixed NET/non-NET tumors with distinct histology and molecular profiles might be better classified as collision tumors rather than MiNENs.

Volume

16

Issue

12

First Page

4738

Last Page

4745

ISSN

1948-5204

Disciplines

Medicine and Health Sciences

PubMedID

39678795

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article

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