Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation.
Publication/Presentation Date
1-22-2024
Abstract
Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in the treatment of PNETs at an advanced stage. Epigenetic alterations profoundly impact the activity of signaling pathways in cancer development, offering potential opportunities for drug development. There is currently a lack of extensive research on epigenetic regulation in PNETs. To fill this gap, we first summarize major signaling events that are involved in PNET development. Then, we discuss the epigenetic regulation of these signaling pathways in the context of both PNETs and commonly occurring-and therefore more extensively studied-malignancies. Finally, we will offer a perspective on the future research direction of the PNET epigenome and its potential applications in patient care.
Volume
25
Issue
2
ISSN
1422-0067
Published In/Presented At
Saleh, Z., Moccia, M. C., Ladd, Z., Joneja, U., Li, Y., Spitz, F., Hong, Y. K., & Gao, T. (2024). Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation. International journal of molecular sciences, 25(2), 1331. https://doi.org/10.3390/ijms25021331
Disciplines
Medicine and Health Sciences
PubMedID
38279330
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article