Impact of Tat Genetic Variation on HIV-1 Disease.
Publication/Presentation Date
1-1-2012
Abstract
The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.
Volume
2012
First Page
123605
Last Page
123605
ISSN
1687-8647
Published In/Presented At
Li, L., Dahiya, S., Kortagere, S., Aiamkitsumrit, B., Cunningham, D., Pirrone, V., Nonnemacher, M. R., & Wigdahl, B. (2012). Impact of Tat Genetic Variation on HIV-1 Disease. Advances in virology, 2012, 123605. https://doi.org/10.1155/2012/123605
Disciplines
Medicine and Health Sciences
PubMedID
22899925
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article