A defect in KCa3.1 channel activity limits the ability of CD8

Authors

• Ameet A Chimote
• Andras Balajthy
• Michael J Arnold
• Hannah S Newton
• Peter Hajdu
• Julianne Qualtieri MD, Lehigh Valley Health NetworkFollow
• Trisha Wise-Draper
• Laura Conforti

Publication/Presentation Date

4-24-2018

Abstract

The limited ability of cytotoxic T cells to infiltrate solid tumors hampers immune surveillance and the efficacy of immunotherapies in cancer. Adenosine accumulates in solid tumors and inhibits tumor-specific T cells. Adenosine inhibits T cell motility through the A

Volume

11

Issue

527

ISSN

1937-9145

Published In/Presented At

Chimote, A. A., Balajthy, A., Arnold, M. J., Newton, H. S., Hajdu, P., Qualtieri, J., Wise-Draper, T., & Conforti, L. (2018). A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11(527), eaaq1616. https://doi.org/10.1126/scisignal.aaq1616

Disciplines

Medicine and Health Sciences

PubMedID

29692361

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article