Morphologic and Molecular Genetic Aspects of Oligodendroglial Neoplasms.
Publication/Presentation Date
1-1-1999
Abstract
Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic component may be debatable. Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms. Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p. Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas. These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.
Volume
1
Issue
1
First Page
52
Last Page
60
ISSN
1522-8517
Published In/Presented At
Bigner, S. H., Rasheed, B. K., Wiltshire, R., & McLendon, R. E. (1999). Morphologic and molecular genetic aspects of oligodendroglial neoplasms. Neuro-Oncology, 1(1), 52-60. doi:10.1093/neuonc/1.1.52
Disciplines
Medical Pathology | Pathology
PubMedID
11550302
Department(s)
Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty
Document Type
Article