Extramedullary haematopoiesis presenting with cardiac tamponade in a patient with polycythaemia vera.
Publication/Presentation Date
8-10-2017
Abstract
A 71-year-old man with a history of polycythaemia vera, diagnosed 4 years ago, presented to the emergency room with shortness of breath. A bedside echocardiogram revealed a large pericardial effusion with features concerning for pericardial tamponade. A left anterior thoracotomy and a pericardial window were emergently performed in the operating room and relieved the patient's symptoms. Histology evaluation of the pericardial fragments and pericardial fluid revealed the presence of trilineage haematopoietic elements without any increase in the blasts. A bone marrow core biopsy revealed an increase in reticulin fibre and increase in the number of blasts of 5%-10%, whereas peripheral blood testing was positive for JAK2 V617F mutation. This case report reviews the literature for cases of extramedullary haematopoiesis associated with myeloproliferative neoplasms.
Volume
2017
ISSN
1757-790X
Published In/Presented At
Haroun, F., Elkis, V., Chen, A., & Lee, E. (2017). Extramedullary haematopoiesis presenting with cardiac tamponade in a patient with polycythaemia vera. BMJ case reports, 2017, bcr2017221316. https://doi.org/10.1136/bcr-2017-221316
Disciplines
Medicine and Health Sciences
PubMedID
28798246
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article