Progressive Supranuclear Palsy with Dementia: Cortical Pathology.
Publication/Presentation Date
4-1-1999
Abstract
Patients with progressive supranuclear palsy (PSP) often develop dementia, and cortical pathology has been documented in PSP. However, there are no reports correlating dementia in PSP with cortical pathology. We hypothesized that cases of PSP presenting with cognitive impairment would have more severe cortical tau pathology than those without. We compared 7 cases of PSP presenting with cognitive deficits (group 1) with 4 cases of PSP that did not (group 2). The subcortical tau pathology was almost identical in both groups. The cortical tau pathology was strikingly different in group 1, in which it was on average moderate, compared with group 2, in which it was minimal. The accumulation of cortical neuronoglial tau in PSP cases with dementia suggests that neurofibrillary pathology is central to the cause of dementia in PSP.
Volume
58
Issue
4
First Page
359
Last Page
364
ISSN
0022-3069
Published In/Presented At
Bigio EH; Brown DF; White CL 3rd, Journal Of Neuropathology And Experimental Neurology [J Neuropathol Exp Neurol], ISSN: 0022-3069, 1999 Apr; Vol. 58 (4), pp. 359-364
Disciplines
Medical Pathology | Pathology
PubMedID
10218631
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=10218631&site=ehost-live&scope=site
Department(s)
Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty
Document Type
Article