Human Telomerase RNA Expression and MIB-1 (Ki-67) Proliferation Index Distinguish Hemangioblastomas From Metastatic Renal Cell Carcinomas.
Hemangioblastomas are low-grade, capillary rich neoplasms of the cerebellum and spinal cord that can occur sporadically or in the setting of Von Hippel-Lindau syndrome. The present study analyzed the utility of proliferation potential in differentiating hemangioblastoma from RCC metastatic to the central nervous system using a MIB-1 (Ki-67) labeling index and assessment of expression of the RNA component of telomerase. Immunohistochemical analysis for epithelial membrane antigen (EMA) and MIB-1 was performed on paraffin-embedded sections of 27 hemangioblastomas and 5 RCC metastatic to the central nervous system. All but one hemangioblastoma demonstrated low or negative MIB-1 immunoreactivity, while 4 of 5 RCC metastases had moderate or high labeling indices. Telomerase RNA expression was assessed in 10 hemangioblastomas and in all 5 metastatic RCC by in Situ hybridization. All 10 hemangioblastomas demonstrated a lack of expression of telomerase RNA, while all 5 metastatic RCCs showed moderate to strong expression. Our results suggest that the MIB-1 labeling index is useful in differentiating hemangioblastoma from metastatic RCC and assessment of telomerase expression can also provide novel information on the difference in growth potential of these tumors.
Published In/Presented At
Brown DF; Gazdar AF; White CL 3rd; Yashima K; Shay JW; Rushing EJ, Journal Of Neuropathology And Experimental Neurology [J Neuropathol Exp Neurol], ISSN: 0022-3069, 1997 Dec; Vol. 56 (12), pp. 1349-55Brown DF; Gazdar AF; White CL 3rd; Yashima K; Shay JW; Rushing EJ, Journal Of Neuropathology And Experimental Neurology [J Neuropathol Exp Neurol], ISSN: 0022-3069, 1997 Dec; Vol. 56 (12), pp. 1349-1355
Medical Pathology | Pathology
Department of Pathology and Laboratory Medicine, Pathology Laboratory Medicine Faculty