Streptozotocin-induced diabetic models in mice and rats.
Publication/Presentation Date
3-1-2008
Abstract
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options.
Volume
Chapter 5
First Page
5
Last Page
5
ISSN
1934-8290
Published In/Presented At
Wu, K. K., & Huan, Y. (2008). Streptozotocin-induced diabetic models in mice and rats. Current protocols in pharmacology, Chapter 5, . https://doi.org/10.1002/0471141755.ph0547s40
Disciplines
Medicine and Health Sciences
PubMedID
22294227
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article