Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.
Publication/Presentation Date
7-1-2021
Abstract
The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4-5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were: (i) plasma distribution volume (v
Volume
34
Issue
7
First Page
4516
Last Page
4516
ISSN
1099-1492
Published In/Presented At
Nagaraja, T. N., Elmghirbi, R., Brown, S. L., Rey, J. A., Schultz, L., Mukherjee, A., Cabral, G., Panda, S., Lee, I. Y., Sarntinoranont, M., Keenan, K. A., Knight, R. A., & Ewing, J. R. (2021). Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma. NMR in biomedicine, 34(7), e4516. https://doi.org/10.1002/nbm.4516
Disciplines
Medicine and Health Sciences
PubMedID
33817893
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article