Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.
The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4-5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were: (i) plasma distribution volume (v
Published In/Presented At
Nagaraja, T. N., Elmghirbi, R., Brown, S. L., Rey, J. A., Schultz, L., Mukherjee, A., Cabral, G., Panda, S., Lee, I. Y., Sarntinoranont, M., Keenan, K. A., Knight, R. A., & Ewing, J. R. (2021). Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma. NMR in biomedicine, 34(7), e4516. https://doi.org/10.1002/nbm.4516
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine