Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci.

Publication/Presentation Date

11-1-2002

Abstract

Seven loci that potentially confer susceptibility to inflammatory bowel disease (IBD) or one of its subtypes have been identified to date; however, most are unconfirmed, and the complete set of loci contributing to disease susceptibility has not yet been determined. The authors aim to identify loci contributing to disease susceptibility in an IBD population from Canada and to compare their results in a systematic manner with those of previously published IBD data sets. The authors performed genome-wide linkage analysis on 63 IBD families from Nova Scotia, Canada. They then undertook a meta-analysis to combine the results of their study with those of the four previously published IBD genome-wide scans with complete data reported. Their genome-wide scan identified three regions of suggestive linkage to IBD: 11p, and The locus on chromosome 11p has not been previously reported. Meta-analysis of multiple scans revealed linked regions corresponding to the, and loci. Meta-analysis of linkage data is a powerful approach for identifying and confirming common susceptibility loci and specifically shows that, and are the major, common IBD susceptibility loci in the populations studied thus far.

Volume

8

Issue

6

First Page

375

Last Page

381

ISSN

1078-0998

Disciplines

Medicine and Health Sciences

PubMedID

12454612

Department(s)

Department of Pathology and Laboratory Medicine

Document Type

Article

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