Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
Publication/Presentation Date
10-1-2001
Abstract
Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease. We sought to design a systematic approach for LD mapping and apply it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease. The key issues are: (i) to detect a significant LD signal (ii) to rigorously bound the critical region and (iii) to identify the causal genetic variant within this region. We previously mapped the IBD5 locus to a large region spanning 18 cM of chromosome 5q31 (P
Volume
29
Issue
2
First Page
223
Last Page
228
ISSN
1061-4036
Published In/Presented At
Rioux, J. D., Daly, M. J., Silverberg, M. S., Lindblad, K., Steinhart, H., Cohen, Z., Delmonte, T., Kocher, K., Miller, K., Guschwan, S., Kulbokas, E. J., O'Leary, S., Winchester, E., Dewar, K., Green, T., Stone, V., Chow, C., Cohen, A., Langelier, D., Lapointe, G., … Hudson, T. J. (2001). Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature genetics, 29(2), 223–228. https://doi.org/10.1038/ng1001-223
Disciplines
Medicine and Health Sciences
PubMedID
11586304
Department(s)
Department of Pathology and Laboratory Medicine
Document Type
Article