Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease. We sought to design a systematic approach for LD mapping and apply it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease. The key issues are: (i) to detect a significant LD signal (ii) to rigorously bound the critical region and (iii) to identify the causal genetic variant within this region. We previously mapped the IBD5 locus to a large region spanning 18 cM of chromosome 5q31 (P
Published In/Presented At
Rioux, J. D., Daly, M. J., Silverberg, M. S., Lindblad, K., Steinhart, H., Cohen, Z., Delmonte, T., Kocher, K., Miller, K., Guschwan, S., Kulbokas, E. J., O'Leary, S., Winchester, E., Dewar, K., Green, T., Stone, V., Chow, C., Cohen, A., Langelier, D., Lapointe, G., … Hudson, T. J. (2001). Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature genetics, 29(2), 223–228. https://doi.org/10.1038/ng1001-223
Medicine and Health Sciences
Department of Pathology and Laboratory Medicine